Design parts that fit and print well: dimensions and walls, clearances between parts, which way up to print, and the slicer's trade-offs between time, plastic and strength. Each idea on a board first, then in Tinkercad and on the printer.
Dimensions and walls, and clearances so parts fit.
A box has a wall on every side, so its inside is the outside minus two walls. To fit something inside, start from the thing: its size, plus a gap each side, plus a wall each side, gives the outside.
Drawn the same size, a printed peg won't go in its hole: printers make holes smaller and pegs bigger. Plan a clearance: about 0.2–0.4 mm for a sliding fit, less for a tight press fit. Every printer differs, so calibrate with a test card.
Which way up, and the slicer's settings.
A printer builds in layers: an overhang more than about 45° from vertical needs supports, and a part is weakest across its layer lines. Choose the way up that needs no supports and runs the layers along the load.
The slicer's settings trade time and plastic for finish and strength. Halving the layer height doubles the time. Infill past about 20–30% costs a lot for little strength; extra walls add more strength for less.
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